Introducing IMCUSTOMEYE, bringing light-based technologies to improve eye diagnostics and personalized surgery
by Susana Marcos, CSIC, IMCUSTOMEYE Project Coordinator
IMCUSTOMEYE is an European Consortium of academic experts in ocular imaging and ocular biomechanics, eye clinics and companies, delivering a new technology to improve ocular diagnostics based on biomechanical biomarkers and personalized treatment.
The cornea is the most external lens in the eye. Along with the crystalline lens, it projects the images of the outside world onto the retina. The cornea is a transparent dome and its structural integrity relies on a finely interleaved collagen fibers. The regular shape of the cornea is therefore the result of its biomechanical rigidity. However, the cornea is not a piece of plastic, and different corneas may respond differently to mechanical stimuli.
In several pathologies, such as keratoconus, the corneal weakens locally, resulting in corneal bulging and vision distortion. Keratoconus affects 1% of the population and treatment requires implating a supporting structure inside the cornea (intracorneal ring segments) or stiffening the cornea instilling a dye and irradiating with light (a technique called keratoconus).
There are other ocular conditions in which the cornea is reshaped or surgically open. These conditions are highly prevalent, such as myopia that affects 30% of the population in western countries and 90% in some Asian populations; presbyopia, the age-related loss of dynami focusing capacity, which affecs 100% of people older than 45; and cataract, the loss of transparency with affects 50% of the population older than 65. In corneal refractive surgery, used to correct eye’s refractive errors a laser is used to evaporate or remove corneal tissue to sculpt the cornea into a different shape. Alternatively, new techniques are being developed where biomaterials or tissue is implanted in the cornea to correct presbyopia. In cataract surgery, an intraocular lens is implanted through an incision that needs to be made in the cornea. While all these treatments rely to a larger or lesser extent on the mechanical response of the cornea, today there is no clinical instrument that either detects corneal mechanical abnormalities, or can help in predicting the mechanical response to surgery.
IMCUSTOMEYE, a Project funded by the European Commission Horizon 2020 program addresses this unmet medical need. IMCUSTOMEYE has gathered a highly internatonally reputed multidisciplinary group of experts in academia, industry and clinic to deliver and demonstrate a new clinical instrument which will put Europe in the forefront of personalized diagnostics in opthalmology.
The Project is Coordinated by VioBio Lab at the National Research Council (CSIC) in Spain, a group that has pioneered multiple optical imaging eye diagnostics and includes world leaders in biomedical optics and photonics at the Institute of Chemistry and Physics, of the Polish Academy of Sciences and National University of Ireland, Galway, and internationally reputed engineers experts in corneal biomechanics from the University of Liverpool.
International companies, selected for their unique technical expertise in the ophthalmic industry and strategic position in the field. 2EyesVision in Spain,which has launched headmounted diagnostic tolos to help in intraocular lens selection in cataract surgery. Oculus in Germany , with a large portfolio of clinical instruments, including the Corvis corneal deformation imaging Optimeyes in Switzerland, with the only software worldwide to guide opthalmic surgical procedures. And IROC in Switzerland, and expert in bridging technology from the lab into a product in the ophthalmic market will ensure an efficient translation of the front-end laboratory designs and prototypes into a viable clinical instrument.
IMCUSTOMEYE’s team also includes most acclaimed ophthalmology clinics, Moorfields Eye Hospital and Instituto Oftalmologico Fernandez Vega, both with flows of thousands of patients day and high clinical standards. The pilot clinical studies with the developed intrumentation will proof the technology and the expected benefits for patients.