Accessing depth-resolved high spatial frequency content from the oCT signal, published in scientific reports
Optical coherence tomography (OCT) is a rapidly evolving technology with a broad range of applications, including biomedical imaging and diagnosis. Conventional intensity-based OCT provides depth-resolved imaging with a typical resolution and sensitivity to structural alterations of about 5–10 microns. It would be desirable for functional biological imaging to detect smaller features in tissues due to the nature of pathological processes. In this article, researchers from the National University of Ireland Galway, perform the analysis of the spatial frequency content of the OCT signal based on scattering theory. We demonstrate that the OCT signal, even at limited spectral bandwidth, contains information about high spatial frequencies present in the object which relates to the small, sub-wavelength size structures. Presented results provide a theoretical and experimental basis to substantially improve the sensitivity of OCT to structural alterations at clinically relevant depths.
Full reference: Alexandrov, S., Arangath, A., Zhou, Y. et al. "Accessing depth-resolved high spatial frequency content from the optical coherence tomography signal". Sci Rep 11, 17123 (2021). https://doi.org/10.1038/s41598-021-96619-7
Full article here
In the past months, Imcustomeye partners have presented multiple results of the project on corneal biomechanics at several international congresses including ARVO 2021 Annual Meeting, OSA Biophotonics Congress 2021, SPIE Conference "Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine" and European Conferences on Biomedical Optics.
ARVO is the largest and most respected eye research organization in the world, with 11,000 members worldwide, and its congress takes place every year playing a key role for research in vision and ophthalmology. This year Judith Birkenfeld's poster on first results with the newest device ImTOPScanner was designated Hot Topic by the organization. Here are the Imcustomeye contributions:
- Judith S. Birkenfeld; Andrea Curatolo; Ashkan Eliasy et al. “Improved detection of corneal deformation asymmetries in keratoconus patients using multi-meridian deformation imaging" Investigative Ophthalmology & Visual Science Vol.62, 2031 (2021)
- Lupe Villegas; James Germann; Susana Marcos. "Biomechanical effects of Scleral crosslinking using Rose Bengal/Green-light and Rivoflavin/UVA". Investigative Ophthalmology & Visual Science Vol.62, 2281 (2021)
- Ashkan Eliasy; Bernardo Teixeira Lopes; Ahmed Abass et al. "Evaluation of Stress-Strain Index (SSI2) in Healthy and Keratoconic corneas". Investigative Ophthalmology & Visual Science Vol.62, 777 (2021)
- Bernardo T Lopes; Ahmed Abass; Ashkan Eliasy; Haixia Zhang; Ahmed Elsheikh. "A New Method to Describe Cone Shape in Keratoconic Corneas". Investigative Ophthalmology & Visual Science Vol.62, 2025 (2021)
OPTICA, formerly OSA, and SPIE are international professional societies working to advance optics and photonics. Imcustomeye has contributed with the following talks at conferences organized by these societies:
- Andrea Curatolo, Angela Pachacz, Jedrzej Solarski et al. "Corrections of motion artifacts in dynamic low-cost, swept-source optical coherence tomography" in Biophotonics Congress 2021. OSA Technical Digest (Optical Society of America), paper DTh1A.4 (2021)
- Karol Karnowski, Jedrzej Solarski, Andrea Curatolo et al. "Corrections of axial shift artifact in dynamic swept-source optical coherence tomography" in SPIE BiOS 2021. Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV, Proceedings Vol. 11630 (2021).
- Judith S. Birkenfeld, David Bronte-Ciriza, Andrés de la Hoz et al. "Proof-of-concept method to estimate scleral mechanical properties from air-puff Optical Coherence Tomography". European Conferences on Biomedical Optics 2021.